Why is it important to maintain the pH of blood and tissue fluids within normal limits? Check all that apply. Check All That Apply a) Most enzymes require an acidic pH to function properly. b) Slight deviations from normal pH can shut down metabolic pathways. c) The structure and function of macromolecules are pH dependent. d) Hormones require a blood pH of at least 77 to function, e) A drop in blood pH causes dehydration