What is the cause and characteristics features of Primary Myelofibrosis (PMF) a.k.a Chronic Idiopathic Myelofibrosis (CIMF)?

a) Cause: Dysregulation of tyrosine kinase signaling
b) Cause: Genetic mutation in the TP53 gene
c) Cause: Excessive production of erythropoietin
d) Cause: Autoimmune destruction of bone marrow