English colonists arrived in the Tidewater way before the 1700s, with Jamestown being established in the tidewater region in 1607. More English colonists arrived in New England in the 1620s with the Mayflower. And the Middle Atlantic was widely settled, first by the Dutch and later by the British and even the Swedes, as early as the 1630s.
The Georgia and Florida areas were also settled very early, and way earlier than the 1700s, but mostly by the Spanish. I'm confused by what the question means by is asking for a region that was not a "main area of settlement," but since the Georgia/Florida area is the outlier of the four choices, I would pick C.
