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The figure below shows the incidence of Bruton's syndrome in the three generations of a family. Bruton syndrome is a rare genetic disorder that is characterized by the mutation in a o gene that prevents the development of certain immune cells. It is an X-linked recessive trait. Determine the genotypes of the individuals in the chart. Let [tex]X^{B}[/tex] represent the dominant Bruton allele and [tex]X^{b}[/tex] represent the recessive Bruton allele.

The figure below shows the incidence of Brutons syndrome in the three generations of a family Bruton syndrome is a rare genetic disorder that is characterized b class=

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The genotype of the individuals is found below.

Genotypes

The disease is X-linked and recessive.  

Males are XY while females are XX. Males only need one recessive allele to become affected. Thus:

  • affected males will be [tex]X^bY[/tex] while unaffected males will be [tex]X^BY[/tex]
  • affected females will be [tex]X^bX^b[/tex], unaffected females will be [tex]X^BX^b[/tex] or [tex]X^BX^B[/tex]

Following these rules, the genotypes of individuals in the figure will be as follows:

  1. [tex]X^BY[/tex]          2.  [tex]X^bX^b[/tex]       3.  [tex]X^BY[/tex]       4.  [tex]X^BX^b[/tex] or [tex]X^BX^B[/tex]

    5.   [tex]X^bY[/tex]         6.  [tex]X^bY[/tex]          7.   [tex]X^bX^b[/tex]     8.  [tex]X^BY[/tex]  

    9.   [tex]X^BX^b[/tex] or [tex]X^BX^B[/tex]   10.   [tex]X^bY[/tex]     11.   [tex]X^bY[/tex]      12.   [tex]X^bY[/tex]

     13.  [tex]X^bX^b[/tex]

More on X-linked diseases can be found here: https://brainly.com/question/14889166

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