During sporulation in Bacillus subtilis, the response regulator that positively controls many genes needed for sporulation and negatively controls genes not needed during sporulation is SpoOA.
- In Bacillus subtilis, sporulation entails asymmetric cell division followed by differentiation into the mother cell and the endospore. Numerous proteins make up the endospore coat, a thick shell that shields the bacterial DNA from stress.
- Spo0A, a transcription factor from the response regulator family, controls gene transcription at the start of sporulation in Bacillus subtilis.
- Traditionally, Spo0A has been thought to as the main regulator for entry into development.
- The primary regulator of sporulation, the transcription factor Spo0A, is phosphorylated as a result of the activation of histidine sensor kinases (such as KinA, KinB, and KinC), which shuttle phosphate via an extended phosphorelay.
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