During the complete catabolism of a molecule of glucose by aerobic cellular respiration, oxidative phosphorylation accounts for how many times more ATP than does substrate-level phosphorylation

Respuesta :

About 4 times more ATP is generated during oxidative phosphorylation than substrate-level phosphorylation.

Oxidative phosphorylation:

In the metabolism process known as oxidative phosphorylation, also known as electron transport-linked phosphorylation or terminal oxidation, cells employ catalysts to oxidize carbohydrates, liberating chemical energy and producing adenosine triphosphate (ATP) as a consequence.

  • According to some modern studies, the ATP output after aerobic respiration is only approximately 30-32 ATP molecules /molecule of glucose, rather than 36-38, because:

During oxidative phosphorylation,

  • the ATP: NADH+H+ and ATP: FADH2 ratios appear to be 2.5 and 1.5 instead of 3 and 2, respectively.

Substrate level phosphorylation:

  • Substrate-level phosphorylation is a metabolic activity that produces ATP or GTP by the direct transfer of a phosphoryl (PO3) group from another phosphorylated chemical to ADP or GDP.
  • Substrate level phosphorylation happens via glycolysis and the Krebs cycle. It happens in two phases during glycolysis, and because 2 molecules are involved, it eventually creates 4 ATP from a glucose molecule.
  • As a result, the total ATP molecules generated from substrate-level phosphorylation of a glucose molecule during aerobic respiration will be 4+2 = 6.

Therefore, it is concluded that ATP generated during oxidative phosphorylation is 30-6=24 or 32-6=26 i.e., about 4 times than substrate-level phosphorylation.

Learn more about substrate level phosphorylation here:

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