CD8+ type of cytotoxic T cells responds to foreign antigens only in association with class I MHC glycoproteins.
Cytotoxic T cell is a particular class of immune cell that is capable of eliminating specific types of cells, such as virus-infected cells, cancer cells, and alien cells. To destroy cancer cells, cytotoxic T cells can be isolated from other blood cells, cultured in a lab, and then administered to a patient.
Helper T cells binding to a processed antigen on the same dendritic cell as the MHC-class II presenting a processed cancer cell antigen enhances cytotoxic T-cell complete activation. Cytotoxic T cells release two cytokines in particular, TNF-alpha and IFN-gamma, which facilitate the activation of macrophages.
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