Guanine pairs with cytosine using three noncovalent hydrogen bonds, while adenine pairs with thymidine using two noncovalent hydrogen bonds.
Cytosine and guanine are joined by three hydrogen bonds. The Watson and Crick bases differ from one another in strength as a result. Thymine and adenine bonded base pairs in DNA are weaker than guanine and cytosine bonded base pairs. Size and structure of the specific nucleotides cause Adenine and Thymine to always pair together while Cytosine and Guanine always pair together.
Adenine and thymine can make two hydrogen bonds, while cytosine and guanine can form three hydrogen bonds. Or, to put it more simply, A and G form bonds. Because each base can only link with one other base, the process is known as complementary base pairing.
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