The symptoms of an immune complex reaction are due to complement fixation.
When antigen-antibody (immune) complexes are deposited in tissues, Type III, or immune-complex, reactions which are characterized by tissue damage brought on by complement activation. The same antibody classes that take part in type II reactions are implicated here. —IgG.
A typical immunological response includes immune complexes. Immune complexes can, however, lead to autoimmune diseases, infections, and cancers when they build up in the blood.
An enzyme complex called C4bC2a breaks down the complement protein C3 into the anaphylatoxin subtypes C3a and C3b. C1q can be activated by apoptotic and necrotic cells, as well as by acute phase proteins such C-reactive protein, in addition to IgG and IgM immune complexes.
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