Fred Griffith scientist's work with Streptococcus pneumoniae in the late 1920s provided early evidence that DNA was the genetic material of cells.
Frederick Griffith was the first to identify bacterial transformation, in which a bacterium's structure and function change, in 1928 while working to create a pneumonia vaccine. He was researching both virulent and nonvirulent Streptococcus pneumoniae.
In the pivotal experiment, Frederick Griffith (1928) combined live R and S that had been destroyed by heat; he then injected the mixture into mice; the animals perished. The tissues of the dead mouse contained living, smooth-coated bacteria resembling S.
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