Respuesta :
Dihydropyridine receptor is an l-type calcium channel in the muscle cell membrane, activated upon depolarization, couples the depolarization signal to release calcium.
In skeletal muscle, the dihydropyridine receptor (DHPR), a voltage-dependent calcium channel by nature, mainly serves as a voltage sensor to initiate intracellular calcium release for excitation-contraction coupling.
Excitation-contraction coupling (EC) is a critical step in the contraction of skeletal and cardiac muscle, and it is mediated by interactions between two Ca2+ ion channel proteins called the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR).
Different cell types, including skeletal and cardiac muscle, express the voltage-gated Ca2+ channels dihydropyridine receptors (DHPRs) and the intracellular Ca2+ release channels ryanodine receptors (RyRs).
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