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Which of the following does not represent a genetic change that can change a proto-oncogene into an oncogene?
all of the listed responses are correct
point mutation within a control element
translocation or transposition
gene amplification
point mutation within the gene
If a proto-oncogene somehow becomes mutated, then it is possible it will become an oncogene. Translocations and transpositions of the proto-oncogene, duplications of the proto-oncogene, and point mutations in a control element for a proto-oncogene can lead to the production of excess growth-stimulating protein, while point mutations within the gene itself might lead to the production of hyperactive or degradation-resistant protein.

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Genetic changes that can convert a proto-oncogene to an oncogene are:

  1. point mutation within a control element
  2. translocation or transposition
  3. gene amplification
  4. point mutation within the gene

Proto-oncogene is a normal gene involved in the growth and development of the body. However the gene has the potential to become cancerous  when it receives certain cues or signals of mutation.

Point mutation is the type of genetic mutation where the change occurs in a single base pair of the DNA. The change could be deletion, addition or substitution. Diseases like thalassemia, sickle cell disease, hemophilia, etc. are caused due to point mutations.

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