The correct answer is B. In 1543, Vesalius published in Basel his work in seven volumes "De humani corporis fabrica", an innovative work of human anatomy that he dedicated to Charles V.
The work highlights the importance of dissection and what was called the "anatomical" vision of the human body. The term used to title his book, "Fabrica", has architectural connotations. In his description he parts from the bones, ligaments and muscles, which underlie the body structure, to then study the connective or unitive systems (blood vessels and nerves) and the systems that drive life. Of the seven books that comprise the work, the first deals with bones and cartilages; the second is about the muscles and ligaments; in the third, the veins and arteries are described; in the fourth the nerves; in the fifth, the digestive and reproductive systems; in the sixth the heart and the organs that help him like the lungs; the seventh and last is dedicated to the central nervous system and the sense organs.
In addition to making the first valid description of the sphenoid, he showed that the sternum consists of three parts and the sacrum of five; and he carefully described the vestibule inside the temporal bone. He verified Etienne's observations about the valves in the hepatic veins, described the azygos vein, and discovered in the fetus the channel that connects the umbilical vein and the inferior vena cava, henceforth called ductus venosus. He also described the omentum, and its connections to the stomach, spleen, and colon; offered the first correct notions about the structure of the pylorus; and observed the small size of the vermiform appendix in men; gave the first valid descriptions of the mediastinum and the pleura and the most correct explanation of the anatomy of the brain performed to date. This book was made possible thanks to the help given by a judge giving him corpses of murderers.
